Endocrine Abstracts

Obesity is commonly ascribed to an imbalance between caloric intake and energy expenditure, but a growing body of evidence underscores the contributions of other factors in the obesity epidemic. We found that exposure of F0 animals to TBT throughout pregnancy and lactation predisposed male F4 descendants of TBT-treated animals to obesity when challenged with a higher fat diet. The TBT group showed impaired ability to mobilize fat during fasting and elevated serum leptin levels...